| dc.creator |
Saidi, Rukia |
|
| dc.creator |
Shirima, Gabriel |
|
| dc.creator |
Buza, Joram |
|
| dc.creator |
Kasanga, Christopher |
|
| dc.date |
2020-12-29T09:23:16Z |
|
| dc.date |
2020-12-29T09:23:16Z |
|
| dc.date |
2020-09 |
|
| dc.date.accessioned |
2022-10-25T09:21:00Z |
|
| dc.date.available |
2022-10-25T09:21:00Z |
|
| dc.identifier |
2141-2529 |
|
| dc.identifier |
https://dspace.nm-aist.ac.tz/handle/20.500.12479/1072 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/95352 |
|
| dc.description |
This research article Journal of Veterinary Medicine and Animal Health, Vol. 12(3), July-September 2020 |
|
| dc.description |
Infectious bursal disease (IBD) is a viral infection that affects young chicks. The IBD outbreaks in
vaccinated chickens are reported in Tanzania frequently. The current study was conducted to find out
the possible causes of vaccination failure focusing on knowledge and practices of vaccine sellers and
users, the immunogenic potential of currently used vaccine and the phylogenetic relationship between
the vaccine and the field strains. A cross-sectional study was performed to gather information on
knowledge and practices from 384 poultry farmers and 20 veterinary outlets in Dar es Salaam. Results
revealed inadequate knowledge of farmers in vaccine handling and administration and also breaches in
the cold chain maintenance by vaccine sellers was apparent. A total of 60 chicks were experimentally
vaccinated with Virgo 7 strain vaccine and titers of induced antibodies assessed. The vaccine induced
adequate antibodies against IBDV, confirming its immunogenic efficacy. Isolated nucleic acids from the
vaccine and field strains were sequenced and result shows that IBDV field isolates, are genetically
different from the vaccine strains used in the country. The field isolates belong to the vvIBDV African
types, while the vaccines belong to the vvIBDV European/Asian or classical virulent types. Putting
together results from this study reveals multiple possible reasons which may contribute to vaccine
failures. These include poor vaccine handling by farmers and vaccine sellers and the genetic disparity
between the field and vaccine strains. It is therefore recommended that veterinary regulatory
authorities should ensure good vaccine handling practices and considering local virus isolates during
vaccine development. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Journal of Veterinary Medicine and Animal Health |
|
| dc.subject |
Infectious bursal disease (IBD) |
|
| dc.subject |
Infectious Bursal Disease Virus (vvIBDV) |
|
| dc.subject |
Phylogenetic analysis |
|
| dc.subject |
Poultry farmers and antibodies |
|
| dc.title |
Factors associated with infectious bursal disease vaccination failure in Dar es salaam, Tanzania |
|
| dc.type |
Article |
|