This research article published by MDPI, 2019Weather conditions are among the major factors leading to the increasing greenhouse gas (GHG) fluxes from the agricultural soils. In this study, variations in the soil GHG fluxes with precipitation and soil temperatures at different elevation ranges in banana–coffee farms, in the Wakiso District, Uganda, were evaluated. The soil GHG fluxes were collected weekly, using the chamber method, and analyzed by using gas chromatography. Parallel soil temperature samples were collected by using a REOTEMP soil thermometer. Daily precipitation was measured with an automated weather station instrument installed on-site. The results showed that CO2, N2O, and CH4 fluxes were significantly different between the sites at different elevation ranges. Daily precipitation and soil temperatures significantly (p < 0.05) affected the soil GHG fluxes. Along an elevation gradient, daily precipitation and soil temperatures positively associated with the soil GHG fluxes. The combined factors of daily precipitation and soil temperatures also influence the soil GHG fluxes, but their effect was less than that of the single effects. Overall, daily precipitation and soil temperatures are key weather factors driving the soil GHG fluxes in time and space. This particular study suggests that agriculture at lower elevation levels would help reduce the magnitudes of the soil GHG fluxes. However, this study did not measure the soil GHG fluxes from the non-cultivated ecosystems. Therefore, future studies should focus on assessing the variations in the soil GHG fluxes from non-cultivated ecosystems relative to agriculture systems, at varying elevation ranges.