| dc.creator |
Vianney, John-Mary |
|
| dc.creator |
McCullough, Monica J. |
|
| dc.creator |
Gyorkos, Amy M. |
|
| dc.creator |
Spitsbergen, John M. |
|
| dc.date |
2020-02-12T06:45:51Z |
|
| dc.date |
2020-02-12T06:45:51Z |
|
| dc.date |
2012 |
|
| dc.date.accessioned |
2022-10-25T09:21:12Z |
|
| dc.date.available |
2022-10-25T09:21:12Z |
|
| dc.identifier |
DOI 10.1007/s11515-012-1201-7 |
|
| dc.identifier |
http://dspace.nm-aist.ac.tz/handle/123456789/550 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/95486 |
|
| dc.description |
This research articles published by Higher Education Press and Springer-Verlag Berlin Heidelberg, 2012 |
|
| dc.description |
The focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor (GDNF)
for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances
maintenance and survival of both developing and mature motor neurons in vivo and in vitro. GDNF aids in
neuromuscular junction formation, maintenance, and plasticity, where skeletal muscle-derived GDNF may be
responsible for this phenomenon. Increased levels of physical activity can increase GDNF protein levels in skeletal
muscle, where alterations in acetylcholine and acetylcholine receptor activation may be involved in regulation of these
changes observed. With inactivity and disuse, GDNF expression shows different patterns of regulation in the central and
peripheral nervous systems. Due to its potent effects for motor neurons, GDNF is being extensively studied in
neuromuscular diseases. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Higher Education Press and Springer-Verlag Berlin Heidelberg |
|
| dc.subject |
glial cell line-derived neurotrophic factor |
|
| dc.subject |
neuromuscular junction |
|
| dc.subject |
motor neurons |
|
| dc.subject |
skeletal muscle |
|
| dc.title |
Exercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular system |
|
| dc.type |
Article |
|