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A computer-based approach for developing linamarase inhibitory agents

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dc.creator Paul, Lucas
dc.creator Mudogo, Celestin
dc.creator Mtei, Kelvin
dc.creator Machunda, Revocatus
dc.creator Ntie-Kang, Fidele
dc.date 2020-06-10T10:52:12Z
dc.date 2020-06-10T10:52:12Z
dc.date 2020-04-18
dc.date.accessioned 2022-10-25T09:24:38Z
dc.date.available 2022-10-25T09:24:38Z
dc.identifier https://doi.org/10.1515/psr-2019-0098
dc.identifier https://dspace.nm-aist.ac.tz/handle/20.500.12479/779
dc.identifier.uri http://hdl.handle.net/123456789/95632
dc.description This research article published by Walter de Gruyter GmbH, 2020
dc.description Cassava is a strategic crop, especially for developing countries. However, the presence of cyanogenic compounds in cassava products limits the proper nutrients utilization. Due to the poor availability of structure discovery and elucidation in the Protein Data Bank is limiting the full understanding of the enzyme, how to inhibit it and applications in different fields. There is a need to solve the three-dimensional structure (3-D) of linamarase from cassava. The structural elucidation will allow the development of a competitive inhibitor and various industrial applications of the enzyme. The goal of this review is to summarize and present the available 3-D modeling structure of linamarase enzyme using different computational strategies. This approach could help in determining the structure of linamarase and later guide the structure elucidation in silico and experimentally
dc.format application/pdf
dc.language en
dc.publisher Walter de Gruyter GmbH
dc.subject Cassava
dc.subject Structural determination
dc.subject Computational strategies
dc.title A computer-based approach for developing linamarase inhibitory agents
dc.type Article


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