| dc.creator |
Mbukwa, Elbert A. |
|
| dc.creator |
Chacha, Musa |
|
| dc.creator |
Majinda, Runner R. T. |
|
| dc.date |
2016-06-15T20:55:00Z |
|
| dc.date |
2016-06-15T20:55:00Z |
|
| dc.date |
2007-01 |
|
| dc.date.accessioned |
2018-03-27T08:54:31Z |
|
| dc.date.available |
2018-03-27T08:54:31Z |
|
| dc.identifier |
Mbukwa, E., Chacha, M. and Majinda, R.R., 2007. Phytochemical constituents of Vangueria infausta: their radical scavenging and antimicrobial activities. Arkivoc, 9, pp.104-112. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2495 |
|
| dc.identifier |
10.3998/ark.5550190.0008.912 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/2495 |
|
| dc.description |
A new biflavonoid, 5,7,3',5'',7'',4'''-hexahydroxy (4'-O-3''')-biflavone (1) and a polyketide derivative, methylcylohex-1-ene (3) [previously reported only as a synthetic compound] were isolated from aerial parts of Vangueria infausta. In addition, eight other known flavonoids viz. (-)-epicatechin, epiafzelechin, dihydrokaempferol, quercetin, luteolin (2), dihydroquercetin-3'-O-glucoside, daidzein and genistein were also isolated from this plant. Structures were identified using 1D-and 2D NMR experiments as well as ESI-MS, IR and UV spectra. The new biflavonoid 1 showed higher radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) reagent compared to ascorbic acid (standard) using a spectrophotometric method. Compound 1 was less sensitive to Gram-positive and Gram-negative bacterial strains and yeast (Candida mycoderma) compared to luteolin and quercetin on the Bioautographic Agar Overlay Assay. |
|
| dc.language |
en |
|
| dc.subject |
Vangueria infausta |
|
| dc.subject |
Flavonoids |
|
| dc.subject |
Polyketide derivative |
|
| dc.subject |
DPPH |
|
| dc.subject |
Antibacterial |
|
| dc.subject |
Antifungal |
|
| dc.title |
Phytochemical Constituents of Vangueria Infausta: Their Radical Scavenging and Antimicrobial Activities |
|
| dc.type |
Journal Article, Peer Reviewed |
|