| dc.creator |
Malebo, Hamisi M. |
|
| dc.creator |
Kihampa, Charles |
|
| dc.creator |
Mgina, Clarence A. |
|
| dc.creator |
Sung’hwa, Fortunatus |
|
| dc.creator |
Waibel, Reiner |
|
| dc.creator |
Jonker, Stephan A. |
|
| dc.creator |
Nkunya, Mayunga H. H. |
|
| dc.date |
2016-06-15T20:56:41Z |
|
| dc.date |
2016-06-15T20:56:41Z |
|
| dc.date |
2014 |
|
| dc.date.accessioned |
2018-03-27T08:54:28Z |
|
| dc.date.available |
2018-03-27T08:54:28Z |
|
| dc.identifier |
Malebo, H.M., Kihampa, C., Mgina, C.A., Sung’hwa, F., Waibel, R., Jonker, S.A. and Nkunya, M.H., 2014. Antifungal Enantiomeric Styrylpyrones from Sanrafaelia ruffonammari and Ophrypetalum odoratum. Natural products and bioprospecting, 4(2), pp.129-133. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2511 |
|
| dc.identifier |
10.1007/s13659-014-0014-6 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/2511 |
|
| dc.description |
Phytochemical investigation of Sanrafaelia ruffonammari Verd and Ophrypetalum odoratum Diels that belongs to the rare genera confined to East African coastal forests led to the isolation of enantiomeric styrylpyrone dimer, (±)-5-methoxy-7-phenyl-[4-methoxy-2-pyronyl]-1-(E)-styryl-2-oxabicyclo-[4.2.0]-octa-4-en-3-one (1) alongside (+)-6-styryl-7,8-epoxy-4-methoxypyran-2-one (2) and the enantiomeric (+)- (3) and (-)-6-styryl-7,8-dihydroxy-4-methoxypyran-2-ones (4). Their structures were established by means of spectroscopic methods. In this paper we reveal for the first time the occurrence of styrylpyrones in East African biodiversity. (+)-6-Styryl-7,8-epoxy-4-methoxypyran-2-one (2) and the dihydroxystyrylpyrone enantiomer (3) showed in vitro antifungal activity against Candida albicans at a concentration of 24.4 and 26.2 µM with zones of inhibition of 17 and 9 mm, respectively. Compound 2 exhibited strong activity in the brine shrimp test with LC50 = 1.7 µg/mL. Their high cytotoxic and antifungal activities render them candidates for further scientific attention for drug development programs against cancer and microbial infections. |
|
| dc.language |
en |
|
| dc.publisher |
Springer Link |
|
| dc.subject |
Sanrafaelia ruffonammari Verd |
|
| dc.subject |
Ophrypetalum odoratum Diels |
|
| dc.subject |
Styrylpyrones |
|
| dc.subject |
Antifungal |
|
| dc.title |
Antifungal Enantiomeric Styrylpyrones from Sanrafaelia ruffonammari and Ophrypetalum odoratum |
|
| dc.type |
Journal Article, Peer Reviewed |
|