| dc.creator |
Marandu, Thomas F. |
|
| dc.creator |
Oduro, Jennifer D. |
|
| dc.creator |
Borkner, Lisa |
|
| dc.creator |
Dekhtiarenko, Iryna |
|
| dc.creator |
Uhrlaub, Jennifer |
|
| dc.creator |
Drabig, Anja |
|
| dc.creator |
Kröger, Andrea |
|
| dc.creator |
Zugich, Janko N. |
|
| dc.creator |
Sain, Luka C. |
|
| dc.date |
2016-07-08T07:23:54Z |
|
| dc.date |
2016-07-08T07:23:54Z |
|
| dc.date |
2015-09 |
|
| dc.date.accessioned |
2018-04-18T10:54:01Z |
|
| dc.date.available |
2018-04-18T10:54:01Z |
|
| dc.identifier |
Marandu, T.F., Oduro, J.D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J.L., Drabig, A., Kröger, A., Nikolich-Zugich, J. and Cicin-Sain, L., 2015. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of virology, 89(22), pp.11715-11717. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2837 |
|
| dc.identifier |
10.1128/JVI.01989-15 · Source: PubMed |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/2837 |
|
| dc.description |
Latent herpesvirus infections alter the immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse CMV, HSV-1 and/or MHV-68 with Influenza, WNV or VSV. We observed no increase in mortality or weight-loss over herpesvirus-negative counterparts and a relative, but no absolute reduction in CD8 responses against acute infections. Therefore, herpesviruses do not appear to increase susceptibility to emerging infections in aging. Copyright © 2015, American Society for Microbiology. All Rights Reserved |
|
| dc.language |
en |
|
| dc.subject |
Immune Protection |
|
| dc.subject |
Latent Herpesviral |
|
| dc.title |
Immune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infections |
|
| dc.type |
Journal Article, Peer Reviewed |
|