| dc.creator |
Takeda, Yoshinori |
|
| dc.creator |
Tanigawa, Naomi |
|
| dc.creator |
Sunghwa, Fortunatus |
|
| dc.creator |
Ninomiya, Masayuki |
|
| dc.creator |
Hagiwara, Makoto |
|
| dc.creator |
Matsushita, Kenji |
|
| dc.creator |
Koketsu, Mamoru |
|
| dc.date |
2016-07-21T18:18:07Z |
|
| dc.date |
2016-07-21T18:18:07Z |
|
| dc.date |
2010-08 |
|
| dc.date.accessioned |
2018-03-27T08:54:57Z |
|
| dc.date.available |
2018-03-27T08:54:57Z |
|
| dc.identifier |
Takeda, Y., Tanigawa, N., Sunghwa, F., Ninomiya, M., Hagiwara, M., Matsushita, K. and Koketsu, M., 2010. Morroniside cinnamic acid conjugate as an anti-inflammatory agent. Bioorganic & medicinal chemistry letters, 20(16), pp.4855-4857. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/3367 |
|
| dc.identifier |
10.1016/j.bmcl.2010.06.095 · Source: PubMed |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/3367 |
|
| dc.description |
Full text can be accessed at
http://www.sciencedirect.com/science/article/pii/S0960894X10008693 |
|
| dc.description |
A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression. |
|
| dc.language |
en |
|
| dc.subject |
Morroniside |
|
| dc.subject |
7-O-Cinnamoylmorroniside |
|
| dc.subject |
Anti-inflammatory activity |
|
| dc.title |
Morroniside cinnamic acid conjugate as an anti-inflammatory agent |
|
| dc.type |
Journal Article |
|