| dc.creator |
Sunghwa, Fortunatus |
|
| dc.creator |
Sakurai, Hiroaki |
|
| dc.creator |
Saiki, Ikuo |
|
| dc.creator |
Koketsu, Mamoru |
|
| dc.date |
2016-07-21T18:26:16Z |
|
| dc.date |
2016-07-21T18:26:16Z |
|
| dc.date |
2009-09 |
|
| dc.date.accessioned |
2018-03-27T08:54:57Z |
|
| dc.date.available |
2018-03-27T08:54:57Z |
|
| dc.identifier |
Sunghwa, F., Sakurai, H., Saiki, I. and Koketsu, M., 2009. Iodine-catalyzed etherification of morroniside. Chemical and Pharmaceutical Bulletin, 57(1), pp.112-115. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/3371 |
|
| dc.identifier |
10.1002/chin.200936185 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/3371 |
|
| dc.description |
Full text can be accessed at
https://www.jstage.jst.go.jp/article/cpb/57/1/57_1_112/_pdf |
|
| dc.description |
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 μM. |
|
| dc.language |
en |
|
| dc.subject |
etherification |
|
| dc.subject |
Morroniside |
|
| dc.subject |
Cytotoxicity |
|
| dc.title |
Iodine-Catalyzed Etherification of Morroniside |
|
| dc.type |
Journal Article |
|