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Catalysis of the Knoevenagel reaction by γ-aminopropylsilica

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dc.creator Macquarrie, Duncan J.
dc.creator Clark, James H.
dc.creator Lambert, Arnold
dc.creator Mdoe, James
dc.creator Priest, Andrew
dc.date 2016-07-22T11:44:22Z
dc.date 2016-07-22T11:44:22Z
dc.date 1997-12
dc.date.accessioned 2018-03-27T08:54:58Z
dc.date.available 2018-03-27T08:54:58Z
dc.identifier Macquarrie, D.J., Clark, J.H., Lambert, A., Mdoe, J.E. and Priest, A., 1997. Catalysis of the Knoevenagel reaction by γ-aminopropylsilica. Reactive and Functional Polymers, 35(3), pp.153-158.
dc.identifier http://hdl.handle.net/20.500.11810/3408
dc.identifier 10.1016/S1381-5148(97)00089-8
dc.identifier.uri http://hdl.handle.net/20.500.11810/3408
dc.description Full text can be accessed at http://www.sciencedirect.com/science/article/pii/S1381514897000898
dc.description The Knoevenagel reaction can be catalysed by γ-aminopropylsilica. Reactions are rapid and essentially quantitative with small amounts of catalyst. A range of aldehydes and ketones can be reacted successfully, the only exceptions being very bulky ketones. The reaction is very dependent on the efficient removal of water, which leads to faster reaction rates and to much higher conversions. The choice of solvent is also extremely important, with nonpolar solvents such as cyclohexane being optimal. Less polar, higher boiling solvents are significantly less effective, even at much higher reaction temperatures. Catalyst poisoning is slow and appears to be due to amide formation on the surface.
dc.language en
dc.title Catalysis of the Knoevenagel reaction by γ-aminopropylsilica
dc.type Journal Article


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