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Household Epidemics: Modelling Effects of Early Stage Vaccination

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dc.creator Shaban, Nyimvua
dc.creator Andersson, Mikael
dc.creator Svensson, Åke
dc.creator Britton, Tom
dc.date 2016-09-21T17:24:23Z
dc.date 2016-09-21T17:24:23Z
dc.date 2009
dc.date.accessioned 2018-03-27T08:58:15Z
dc.date.available 2018-03-27T08:58:15Z
dc.identifier Shaban, N., Andersson, M., Svensson, Å. and Britton, T., 2009. Household epidemics: modelling effects of early stage vaccination. Biometrical Journal, 51(3), pp.408-419.
dc.identifier http://hdl.handle.net/20.500.11810/4176
dc.identifier 10.1002/bimj.200800172
dc.identifier.uri http://hdl.handle.net/20.500.11810/4176
dc.description A Markovian susceptible - infectious - removed (SIR) epidemic model is considered in a community partitioned into households. A vaccination strategy, which is implemented during the early stages of the disease following the detection of infected individuals is proposed. In this strategy, the detection occurs while an individual is infectious and other susceptible household members are vaccinated without further delay. Expressions are derived for the influence on the reproduction numbers of this vaccination strategy for equal and unequal household sizes. We fit previously estimated parameters from influenza and use household distributions for Sweden and Tanzania census data. The results show that the reproduction number is much higher in Tanzania (6 compared with 2) due to larger households, and that infected individuals have to be detected (and household members vaccinated) after on average 5 days in Sweden and after 3.3 days in Tanzania, a much smaller difference.
dc.language en
dc.publisher Wiley
dc.subject Delay time
dc.subject Epidemic model
dc.subject Household
dc.subject Reproduction number
dc.subject Vaccination strategy
dc.title Household Epidemics: Modelling Effects of Early Stage Vaccination
dc.type Journal Article, Peer Reviewed


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