Abstract The purpose of this paper is to examine the factors that affect growth of women businesses in Tanzania. To achieve this objective cross-section survey of women SMEs in Tanzania were examined. A sample of 254 randomly selected from women entrepreneurs from Cloth selling, Whole selling, Retailing, Hair salon, Food vending, Handcraft, Mobile money, Microfinance Institution, Tailoring, Charcoal selling, Fish selling and Vegetable selling businesses in Tanzania were used in the study to test the four hypotheses formulated to meet the study purpose. Using Multiple Linear Regression Analysis, findings indicate that all four factors are barriers for Growth of Women businesses. The study recommends that businesses from Sub Saharan Africa should learn from this study and be alert that training and skills to business owners are the important aspects if they need their businesses to grow.UDBS