Dissertation (MSc Nursing Education)Background: Accidents has been observed to hinder individual development and reduce national economic intensification against expectations of Sustainable Development Goals (SDGs). The presence of users of motorcycles and the associated accidents incursion offer a unique challenge in view of inadequate work force, which is frequently lost. The study-determined effectiveness of participatory training in improving knowledge and skills for basic life support among commercial motorcyclists to address the problem. Methods: It was a quantitative quasi-experimental study targeting 268 commercial motorcyclists sampled randomly from 44 registered parking points. Data were collected using self-administered questionnaire after consent and approval. Participants were grouped into six groups not less than 40 except and trained hourly everyday for each group in specified time. Data was analysed by descriptive and inferential statistics using SPSS Version 20.0. Result: All participants, 252 (100%) were male aged 20-29 years 119 (47.2%), 30-39 years, 95 (37.7%), 40-49 years, 36 (14.3%) and above 50 years were 2 (0.8%). In all participants, 57.5% were not using protective boots when riding motorcycles while 29.7% and 28.6% performed drunken riding often and sometime respectively but 95.2% were not tested using breathalyzer and 94.4% were penalized due to couple of reasons including drunken riding. Knowledge and skills change were statistical significantly, t (251) =-53.65, p<0.001, t (251) =-45.22, p<0.001, respectively and majority of the participants were satisfied towards training rendered with a statistically significant difference of 11.4 (95% CI, 11.1 to 11.7), t (251) = 69.4, p < 0.001. Conclusion: While there was inadequate compliance on road safety practices among commercial motorcyclists, this study concludes that, participatory training is more effective and relevant in improving knowledge and skills on basic life support in the middle of commercial motorcyclists. The current study recommended on enforcing road safety practices among commercial motorcyclists and initiating this kind of informal training to address the road traffic injuries fatalities.