| dc.creator |
Munisi, David Z. |
|
| dc.creator |
Buza, Joram |
|
| dc.creator |
Mpolya, Emmanuel A. |
|
| dc.creator |
Angelo, Teckla |
|
| dc.creator |
Kinung, Safari M. |
|
| dc.date |
2021-05-13T08:28:35Z |
|
| dc.date |
2021-05-13T08:28:35Z |
|
| dc.date |
2017 |
|
| dc.date.accessioned |
2022-10-20T14:01:41Z |
|
| dc.date.available |
2022-10-20T14:01:41Z |
|
| dc.identifier |
Munisi, D. Z., Buza, J., Mpolya, E. A., Angelo, T., & Kinungโhi, S. M. (2017). The efficacy of single-dose versus double-dose praziquantel treatments on Schistosoma mansoni infections: its implication on undernutrition and anaemia among primary schoolchildren in two on-shore communities, northwestern Tanzania. BioMed research international, 2017. |
|
| dc.identifier |
DOI:https://doi.org/10.1155/2017/7035025 |
|
| dc.identifier |
http://hdl.handle.net/20.500.12661/3069 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.12661/3069 |
|
| dc.description |
Full text Article. Also available at https://doi.org/10.1155/2017/7035025 |
|
| dc.description |
Administering more than one treatment may increase Praziquantel cure and egg reduction rates, there by hastening achievement of schistosomiasis transmission control. A total of 431S. Mansoni-infected schoolchildren were randomized to receive either a single or repeated 40 mg/kg Praziquantel dose. Heights, weights, and haemoglobin levels were determined using a stadiometer, weighing scale, and Hemo Cue, respectively. At 8 weeks, cure rate was higher on repeated dose (93.10%) compared to single dose (68.68%) (𝑝 <0.001). The egg reduction rate was higher on repeated dose (97.54%) compared to single dose (87.27%) (𝑝 = 0.0062). Geometric mean egg intensity was lower among those on repeated dose(1.30epg) compared to single dose (3.18epg)(𝑝 = 0.036)butnotat5 (𝑝 > 0.05)and8(𝑝 > 0.05) months with no difference in reinfection rate. No difference in the prevalence of stunting was observed between the two treatment regimens (𝑝 > 0.05) at 8 months, but there was an increase in the prevalence of wasting among those on repeated dose (𝑝 < 0.001). There was an increase in the mean haemoglobin level sat 8 months with no difference between the two arms (𝑝 > 0.05). To achieve reduction of transmission intensity and disease control in highly endemic areas, repeated treatments alone may not be sufficient. This trial was registered with PACTR 201601001416338. |
|
| dc.language |
en |
|
| dc.publisher |
Hindawi Limited |
|
| dc.subject |
Schistosoma mansoni |
|
| dc.subject |
Anaemia |
|
| dc.subject |
Undernutrition |
|
| dc.subject |
Tanzania |
|
| dc.subject |
Schistosomiasis transmission control |
|
| dc.subject |
Schistosomiasis |
|
| dc.subject |
Urinary schistosomiasis |
|
| dc.subject |
Praziquantel chemotherapy |
|
| dc.subject |
Rorya district |
|
| dc.subject |
Double-dose praziquantel |
|
| dc.subject |
Single-dose praziquantel |
|
| dc.title |
The efficacy of single-dose versus double-dose praziquantel treatments on schistosoma mansoni infections: its implication on undernutrition and anaemia among primary schoolchildren in two on-shore communities, Northwestern Tanzania |
|
| dc.type |
Article |
|