Dissertation (MMED Obstetrics and Gynecology)Antepartum hemorrhage contributes to potential fetal-maternal morbidity and mortality despite the availability of antenatal care and comprehensive obstetric care services. Placenta previa and placental abruption are important causes of antepartum hemorrhage. This study aimed to determine clinical predictors of fetal and maternal outcomes among women with antepartum hemorrhage. A hospital-based cross-sectional study was conducted from September 2020 to March 2021 at Dodoma Regional Referral Hospital. The study included all pregnant women with antepartum hemorrhage due to placenta previa and placental abruption from 28 weeks of pregnancy delivered at the hospital during the study period. Binary logistic regression analysis was used to associate between predictors to the fetal and maternal outcomes of antepartum hemorrhage. A total of 57 pregnant women with antepartum hemorrhage due to placenta previa and placental abruption enrolled during the study period. Among participants, 41(71.93%) had a placental abruption and 16(28.07%) had placenta previa. Maternal outcomes were primary postpartum hemorrhage (PPH) 25(43.86%), hypovolemic shock 18(31.58%), coagulopathy (DIC) 11(19.30%), peripartum hysterectomy 9(15.79), acute kidney injury, and one maternal death 1.75% in participants with placental abruption. Fetal outcomes were low Apgar score 34(59.65%), perinatal deaths 33 (57.89%), and preterm deliveries 32(56.14%). Women with placental abruption were five times more likely to have maternal adverse outcomes compared to those who had placenta previa (p=0.0296). Women who had previous caesarian deliveries were five times more likely to have adverse maternal outcomes compared to those who had not (p=0.0279). Women with placental abruption were five times more likely to have adverse fetal outcomes as compared to those with placenta previa (p=0.0294). Antepartum hemorrhage due to placenta previa and placental abruption contributes to significant fetal and maternal morbidity and mortality. Predictors of excessive bleeding can be identified during antenatal care to identify the mothers at risk and prevent serious complications.