Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release

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dc.creatorSong, Sinae
dc.creatorHilonga, Askwar
dc.creatorKim, Hee Taik
dc.date2019-11-13T09:43:10Z
dc.date2019-11-13T09:43:10Z
dc.date2017
dc.date.accessioned2022-10-25T09:24:38Z
dc.date.available2022-10-25T09:24:38Z
dc.descriptionResearch Article published by IOP Publishing
dc.descriptionAbstract. Polycaprolactone (PCL) is an interesting material to apply biomedical field owing to its biodegradability and biocompatibility which is suitable for a specific site with longer healing times. Blending the polymer with other materials has degradation property improved with the effective and economic method. This study was conducted to fabricate supporter based on Polycaprolactone and Rice husk silica (PCL-SiO2) by using electrospinning. Nano-porous silica in the composite was synthesized from rice husk having properties of economic, ecofriendly and high surface area. It drew to enhance the amount of drug loading in the carrier. Electrospinning technique is used to fabricate fibrous component by optimization condition obtained from previous mechanical properties experiments. Release experiment was carried out by the degree of dye absorbance at 544nm by ultraviolet–visible spectroscopy, the RhB in SiO2 alternative drug for modelling of drug release was released for 1 ~ 20 days at 37°C in phosphate buffer. Furthermore, the Mechanical property was confirmed by DSC, TGA. Morphology and degree of biodegradation were shown as SEM images and EDS.
dc.formatapplication/pdf
dc.identifierdoi :10.1088/1742-6596/987/1/012013
dc.identifierhttp://dspace.nm-aist.ac.tz/handle/123456789/517
dc.identifier.urihttp://hdl.handle.net/123456789/95629
dc.languageen
dc.publisherIOP Publishing Ltd
dc.subjectResearch Subject Categories::NATURAL SCIENCES
dc.titleCharacterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release
dc.typeArticle

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