Factors associated with sputum smear conversion and reversion rates among new smear-positive pulmonary tuberculosis patients at Iringa and Dodoma regional referral hospitals: a prospective cohort study

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dc.creatorPazi, Swaleh K
dc.date2019-09-04T06:32:37Z
dc.date2019-09-04T06:32:37Z
dc.date2018
dc.date.accessioned2022-10-20T14:03:15Z
dc.date.available2022-10-20T14:03:15Z
dc.descriptionDissertation (MMED Internal Medicine)
dc.descriptionBackground: Pulmonary tuberculosis smear-positive cases are expected to convert to negative sputum during treatment. Delayed sputum conversion and reversion prolong infectious period. Therefore, understanding associated factors for smear conversion and reversion will help to identify a patient with severe infectious pulmonary tuberculosis before or during treatment. Objective: The aim of this study was to determine sputum conversion and reversion rates and their associated factors among new sputum smear-positive pulmonary tuberculosis (PTB) patients. Methods: This was a prospective hospital-based study done at Iringa and Dodoma Regional Referral Hospitals. A sample size of 131 patients was recruited after being screened for AFB. The analysis was done using STATA version 12, associated factors for early sputum conversion, delayed conversion and reversion were established by univariate and multivariate logistic regression. Results: Of the 131, 98(75%) of the patients enrolled were male. Age 60+ years old aOR:0.07(95%CI:0.006-0.084) not favouring early sputum conversion, current cigarette smoking aOR: 2.892(95%CI: 0.118-0.803) was associated with delayed sputum conversions while sputum reversion was associated with current cigarette smoking a OR:3.616(95%CI:1.220-10.716). Conclusion and Recommendations: Delayed sputum conversion and reversion appear to be common among pulmonary tuberculosis. This data highlights the importance of providing smoking cessation counselling to newly diagnosed PTB patients.
dc.identifierPazi, S.K. (2018). Factors associated with sputum smear conversion and reversion rates among new smear-positive pulmonary tuberculosis patients at Iringa and Dodoma regional referral hospitals: a prospective cohort study. Dodoma: The University of Dodoma
dc.identifierhttp://hdl.handle.net/20.500.12661/1560
dc.identifier.urihttp://hdl.handle.net/20.500.12661/1560
dc.languageen
dc.publisherThe University of Dodoma
dc.subjectSputum smear
dc.subjectSputum
dc.subjectConversion rates
dc.subjectReversion rates
dc.subjectPulmonary tuberculosis
dc.subjectTuberculosis
dc.subjectPTB
dc.subjectTB
dc.subjectDodoma regional referral hospital
dc.subjectIringa regional referral hospital
dc.subjectDodoma
dc.subjectIringa
dc.subjectHospital
dc.titleFactors associated with sputum smear conversion and reversion rates among new smear-positive pulmonary tuberculosis patients at Iringa and Dodoma regional referral hospitals: a prospective cohort study
dc.typeDissertation

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