Article published in a journal titled: Urban Studies and Public Administration Vol. 1, No. 1, 2018Health Literacy significantly contributes towards attaining good health particularly when taken into the context of the interface of humans, animals and the environment. This cross-sectional study assessed health literacy and its connections to other socio-demographic aspects under One Health Approach in Morogoro municipality and Mvomero districts in Tanzania. A structured questionnaire administered through a Computer Aided Personal Interviewing (CAPI) electronic platform was used to collect data from 240 respondents obtained through a multistage sampling procedure. Health Literacy was assessed using context specific assessment tool. IBM-SPSS v20 and Gretl software were used to analyze data. The results revealed Inadequate Health Literacy at 36.3%, Moderate Health Literacy at 30.8% and Adequate Health Literacy standing at 32.9%. There was no association between educational attainment and the level of Health Literacy revealed. Health Literacy was lower among older individuals, with 40.2% of those who had Inadequate Health Literacy were from the elderly age category, more females (56.3%) had Inadequate Health Literacy than males (43.7%), Adequate Health Literacy was observed among married respondents at 65.8% in the category. Health literacy varies across some socio-demographic aspects. It therefore remains imperative that interventions in scale up health literacy by various stakeholders to consider these socio-demographic aspects.Intra-ACP Academic Mobility Scheme