| dc.creator |
Subbiah, Murugan |
|
| dc.creator |
Caudell, Mark |
|
| dc.creator |
Mair, Colette |
|
| dc.creator |
Davis, Margaret |
|
| dc.creator |
Matthews, Louise |
|
| dc.creator |
Quinlan, Robert |
|
| dc.creator |
Quinlan, Marsha |
|
| dc.creator |
Lyimo, Beatus |
|
| dc.creator |
Buza, Joram |
|
| dc.creator |
Keyyu, Julius |
|
| dc.creator |
Call, Douglas |
|
| dc.date |
2020-01-16T09:30:05Z |
|
| dc.date |
2020-01-16T09:30:05Z |
|
| dc.date |
2020-01-13 |
|
| dc.date.accessioned |
2022-10-25T09:20:27Z |
|
| dc.date.available |
2022-10-25T09:20:27Z |
|
| dc.identifier |
31932601 |
|
| dc.identifier |
https://doi.org/10.1038/s41467-019-13995-5 |
|
| dc.identifier |
http://dspace.nm-aist.ac.tz/handle/123456789/527 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/94944 |
|
| dc.description |
The research article published on Nature Communications 2020 |
|
| dc.description |
Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Nature Communications |
|
| dc.rights |
Attribution-NonCommercial-ShareAlike 4.0 International |
|
| dc.rights |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
| dc.subject |
Antimicrobial resistance |
|
| dc.subject |
Developing world |
|
| dc.subject |
Epidemiology |
|
| dc.subject |
Research Subject Categories::NATURAL SCIENCES |
|
| dc.title |
Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania. |
|
| dc.type |
Article |
|