| dc.creator |
Borasio, Gian D. |
|
| dc.creator |
John, Jasson |
|
| dc.creator |
Wittinghofer, Alfred |
|
| dc.creator |
Barde, Y. A. |
|
| dc.creator |
Sendtner, Michael |
|
| dc.creator |
Heumann, Rolf |
|
| dc.date |
2016-07-14T20:56:10Z |
|
| dc.date |
2016-07-14T20:56:10Z |
|
| dc.date |
1989-01 |
|
| dc.date.accessioned |
2021-05-03T13:29:43Z |
|
| dc.date.available |
2021-05-03T13:29:43Z |
|
| dc.identifier |
Borasio, G.D., John, J., Wittinghofer, A., Barde, Y.A., Sendtner, M. and Heumann, R., 1989. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron, 2(1), pp.1087-1096. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/3224 |
|
| dc.identifier |
10.1016/0896-6273(89)90233-X · Source: PubMed |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/3224 |
|
| dc.description |
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the neuronal response to neurotrophic factors in nontransformed cells. We report here that the oncogene protein T24-ras, when introduced into the cytoplasm of freshly dissociated chick embryonic neurons, promotes the in vitro survival and neurite outgrowth of nerve growth factor-responsive dorsal root ganglion neurons, brain-derived neurotrophic factor-responsive nodose ganglion neurons, and ciliary neuronotrophic factor-responsive ciliary ganglion neurons. The proto-oncogene product c-Ha-ras also promotes neuronal survival, albeit less strongly. No effect could be observed with truncated counterparts of T24-ras and c-Ha-ras lacking the 23 C-terminal amino acids including the membrane-anchoring, palmityl-accepting cysteine. These results suggest a generalized involvement of ras or ras-like proteins in the intracellular signal transduction pathway for neurotrophic factors. |
|
| dc.language |
en |
|
| dc.title |
Borasio, G.D. et al. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2, 1087-1096 |
|
| dc.type |
Journal Article, Peer Reviewed |
|