| dc.creator |
Cai-Zhi, Liu |
|
| dc.creator |
Yuan, Luo |
|
| dc.creator |
Samwel Mchele Limbu |
|
| dc.creator |
Li-Qiao, Chen |
|
| dc.creator |
Zhen-Yu, Du |
|
| dc.date |
2019-05-07T13:05:51Z |
|
| dc.date |
2019-05-07T13:05:51Z |
|
| dc.date |
2018-04-12 |
|
| dc.date.accessioned |
2021-05-07T07:47:50Z |
|
| dc.date.available |
2021-05-07T07:47:50Z |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/5222 |
|
| dc.identifier |
http://jeb.biologists.org/content/early/2018/04/11/jeb.179291 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/5222 |
|
| dc.description |
Insulin-like growth factor-1 (IGF-1) plays a crucial role in regulating growth in vertebrates while suppressors of cytokine signaling (SOCS) act as feedback inhibitors of the GH/IGF-1 axis. Although SOCS-2 binds IGF-1 receptor and inhibits IGF-1-induced STAT3 activation, presently there is no clear evidence whether IGF-1 could induce SOCS genes expression. The current study aimed to determine whether IGF-1 could induce the transcription of SOCS in juvenile Nile tilapia (Oreochromis niloticus). We show that there is a common positive relationship between the mRNA expression of IGF-I and SOCS-2 under different nutritional statuses and stimulants, but not the expression of SOCS-1 and SOCS-3 mRNA. Furthermore, rhIGF-1 treatment and transcriptional activity assay confirmed the hypothesis that IGF-1 could induce SOCS-2 expression, while has no effect or even decreased the expression of SOCS-1 and SOCS-3. Overall, we obtained evidence that the transcription of SOCS-2, but not SOCS-1 or SOCS-3 could be induced by IGF signaling, suggesting the SOCS-2 serves as a feedback suppressor of IGF-1 axis in juvenile Nile tilapia. |
|
| dc.description |
The National Basic Research Program of
China (973 program 2014CB138603) and National Natural Science Fund
(31472290 and 31772859). |
|
| dc.publisher |
The Company of Biologists Limited |
|
| dc.subject |
Nile tilapia (Oreochromis niloticus) |
|
| dc.subject |
Insulin-like growth factor |
|
| dc.subject |
Suppressor of cytokine signaling |
|
| dc.subject |
Transcription |
|
| dc.title |
IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus). |
|
| dc.type |
Journal Article, Peer Reviewed |
|