IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus).
| dc.creator | Cai-Zhi, Liu | |
| dc.creator | Yuan, Luo | |
| dc.creator | Samwel Mchele Limbu | |
| dc.creator | Li-Qiao, Chen | |
| dc.creator | Zhen-Yu, Du | |
| dc.date | 2019-05-07T13:05:51Z | |
| dc.date | 2019-05-07T13:05:51Z | |
| dc.date | 2018-04-12 | |
| dc.date.accessioned | 2021-05-07T07:47:50Z | |
| dc.date.available | 2021-05-07T07:47:50Z | |
| dc.description | Insulin-like growth factor-1 (IGF-1) plays a crucial role in regulating growth in vertebrates while suppressors of cytokine signaling (SOCS) act as feedback inhibitors of the GH/IGF-1 axis. Although SOCS-2 binds IGF-1 receptor and inhibits IGF-1-induced STAT3 activation, presently there is no clear evidence whether IGF-1 could induce SOCS genes expression. The current study aimed to determine whether IGF-1 could induce the transcription of SOCS in juvenile Nile tilapia (Oreochromis niloticus). We show that there is a common positive relationship between the mRNA expression of IGF-I and SOCS-2 under different nutritional statuses and stimulants, but not the expression of SOCS-1 and SOCS-3 mRNA. Furthermore, rhIGF-1 treatment and transcriptional activity assay confirmed the hypothesis that IGF-1 could induce SOCS-2 expression, while has no effect or even decreased the expression of SOCS-1 and SOCS-3. Overall, we obtained evidence that the transcription of SOCS-2, but not SOCS-1 or SOCS-3 could be induced by IGF signaling, suggesting the SOCS-2 serves as a feedback suppressor of IGF-1 axis in juvenile Nile tilapia. | |
| dc.description | The National Basic Research Program of China (973 program 2014CB138603) and National Natural Science Fund (31472290 and 31772859). | |
| dc.identifier | http://hdl.handle.net/20.500.11810/5222 | |
| dc.identifier | http://jeb.biologists.org/content/early/2018/04/11/jeb.179291 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11810/5222 | |
| dc.publisher | The Company of Biologists Limited | |
| dc.subject | Nile tilapia (Oreochromis niloticus) | |
| dc.subject | Insulin-like growth factor | |
| dc.subject | Suppressor of cytokine signaling | |
| dc.subject | Transcription | |
| dc.title | IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus). | |
| dc.type | Journal Article, Peer Reviewed |