Methyl Dglucopyranoside from Tulbghia violacea α Extract Induces Apoptosis in Vitro in Cancer Cells
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Description
Pro-apoptotic activity of Tulbghia violacea extracts was evaluated in order to
understand the mechanisms of action that might be related to its traditional
use as anticancer medicine. Apoptosis-guided purification was used to isolate
active compound whose chemical structure was solved by using spectroscopic,
microanalysis and X-ray crystallography techniques. T. violacea extract
kills Chinese hamster ovary cells, MCF7, and HeLa cells through the induction
of apoptosis Methyl--D-glucopyranoside was identified as one of the main
pro-apoptotic compounds present in T. violacea extract. This is the first time
ever demonstration that T. violacea contains methyl -D-glucopyranoside,
which selectively kills cancer cells through apoptosis mechanisms.
Keywords
Apoptosis, Anti-cancer, Methyl-α-D-glucopyranoside, Tulbaghia violacea