Total Synthesis of Ochnaflavone
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Description
The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl
ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of
a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental
conditions for the oxidative cyclization to form ochnaflavone were established.
Keywords
biflavone, diaryl ether, natural products, nucleophilic aromatic substitution, ochnaflavone, tetrahydroochnaflavone