Total Synthesis of Ochnaflavone

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dc.creatorNdoile, Monica
dc.creatorvan Heerden, Fanie
dc.date2018-09-10T11:36:16Z
dc.date2018-09-10T11:36:16Z
dc.date2013
dc.date.accessioned2021-05-03T13:19:55Z
dc.date.available2021-05-03T13:19:55Z
dc.descriptionThe first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental conditions for the oxidative cyclization to form ochnaflavone were established.
dc.identifierhttp://hdl.handle.net/20.500.11810/4869
dc.identifier.urihttp://hdl.handle.net/20.500.11810/4869
dc.subjectbiflavone
dc.subjectdiaryl ether
dc.subjectnatural products
dc.subjectnucleophilic aromatic substitution
dc.subjectochnaflavone
dc.subjecttetrahydroochnaflavone
dc.titleTotal Synthesis of Ochnaflavone
dc.typeJournal Article, Peer Reviewed

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