Information and communication Technologies (ICT) has changed the way people do things, so do the governments service provision. E-government refers to the use of information technologies like wide area network, the internet and mobile computing by government departments and agencies to transform relations with citizens, businesses, and other arms of government. There are benefits in as far as the e-government is concerned, they include: E-Government initiatives improve efficiency, improve access of information, enhance quality of service delivery and improve trust relationship of government and citizens. All these are the E-government roles at President’s office ethics secretariat. E-Government implementation results in huge cost and time savings to governments and citizens, however, there are challenges in implementing e-government which include human, infrastructural, financial, legal framework and political aspects. This study was about examining the practice and role of E-Goverment, a case of President’s office ethics secretariat. The case study research design was applied. The sample size comprised of 60 respondents while simple randomly and purposive sampling techniques were applied. The methods of data collection included questionnaire, interview and observation. According to the findings, the large proportion of respondents revealed that there are challenges which to the large extent hinder effective functioning of E-government roles. These challenges include: human aspects challenges, infrastructure, financial, political and legal framework challenges. It was recommended that there is a need for proper policy and legal framework that can help to support the practice and roles of E-government in ethics secretariat. Furthermore, it was recommended that the ethics secretariat must increase cooperation with various international agencies like USAIDS, CIDA and other stakeholders to invest more on E-government so that they can fully support the system and provide viable infrastructure for the development and practice of E-government.