A Dissertation Submitted in Partial Fulfillment of the Requirements for the Award of Master of Science Degree in Human Resource Management of Mzumbe University, Morogoro, Tanzania.Employee retention is a concern for organizations in this competitive job market because there are a great number of employment opportunities for talented professionals, the higher skilled the employees, the greater the demand for their services. In order to retain the best talents, strategies aimed at satisfying employee’s needs are implemented, the problem remains on how great is the effect of each strategy having toward overall employee’s retention. The primary aim of this study was to assess the factors that most significantly influence employee retention in public organizations in Tanzania, by using Mwanza Regional Secretariat as a case study. The sample size of forty employees, involving top, middle and lower level employees were the respondents in this study. The results of the study shows that job security, training opportunities, salary amounts, working environments, participative decision making, availability of allowances, relationships at work place, retirement benefits plans and promotion opportunities are some of the factors that basically influence employee retention at Mwanza Regional secretariat. The difference come from the implementation, those implemented as required like job security and retirement benefits plans their influence on retention is positive and those poorly implemented they act as a limit to employee retention efforts, which results to labour turnover, transfer of employees, low working moral and partial fulfilment of the organisation objectives. The solution to retention problems at the secretariat is to put more emphasis on financial incentives like increasing employee’s salary because according to the findings the respondents value them more than non financial incentives. The findings of this study can be used by organizations to develop policies, practices, and strategies that would enable higher levels of employee retention and create greater efficiencies in meeting strategic objectives in the public sector, mainly at Mwanza Regional Secretariat.